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Compositions of solutions containing chloride channel activators and inhibitors.
| CFTR activator study | CFTR inhibitor Study | TMEM16A inhibitor study | |
|---|---|---|---|
|
|
|
||
| Inlet 1 | PBS | 5 μM forskolin | PBS |
| Inlet 2 | 30 μM forskolin | 5 μM CFTRinh-172 +5 μM forskolin | 30 μM TMinh-A01 |
| I− flux | 140 mM I− | 140 mM I− | 70 mM I−+ 50 μM ATP |
