Table 3.
Association of physical activity with decline in eGFR in subgroups of participants
| Leisure-Time Physical Activity Level (min/wk) | Adjusted Percent Annual Change in eGFR Cystatin Ca | |||||
|---|---|---|---|---|---|---|
| Participants with No Prevalent Coronary Artery Disease at Baseline (n=138)b | Participants with No Prevalent Diabetes at Baseline (n=119)c | Participants with SPPB ≥8 at Baseline (n=173)d | ||||
| n | Percent Annual Change (95% CI) | n | Percent Change per Year (95% CI) | n | Percent Change per Year (95% CI) | |
| None | 25 | −9.8 (−12.2 to −7.4) | 22 | −10.7 (−14.3 to −7.0) | 27 | −8.9 (−12.3 to −5.5) |
| 1–60 | 38 | −8.0 (−10.2 to −5.8) | 33 | −5.3 (−8.4 to −2.2) | 52 | −7.3 (−10.0 to −4.6) |
| 60–150 | 30 | −7.0 (−9.2 to −4.9) | 23 | −5.5 (−8.8 to −2.1) | 42 | −6.5 (−9.3 to −3.7) |
| ≥150 | 45 | −6.2 (−8.3 to −4.1) | 39 | −4.4 (−7.6 to −1.2) | 52 | −6.0 (−8.6 to −3.4) |
| P value for trend | 0.03 | 0.01 | 0.03 | |||
| Per 60 min/week increment | 0.57 (0.11 to 1.04) | 0.66 (0.09 to 1.23) | 0.57 (0.03 to 1.10) | |||
P values for continuous association (per 60 min/wk increment in physical activity) were 0.02, 0.02, and 0.04 for participants with no prevalent coronary heart disease at baseline, no prevalent diabetes at baseline, and SPPB ≥8 at baseline, respectively. 95% CI, 95% confidence interval.
Adjusted for age, race, sex, site, smoking status, alcohol use, angiotensin-converting enzyme inhibitor use, angiotensin-receptor blocker use, and statin use.
Prevalent coronary artery disease was defined as self-reported previous myocardial infarction, cardiac arrest, coronary artery bypass graft, or percutaneous coronary intervention.
Prevalent diabetes was defined by any of the following: use of an oral hypoglycemic medication or insulin, fasting blood sugar ≥126 mg/dl, nonfasting blood sugar ≥200 mg/dl, or hemoglobin A1c ≥6.5%.
A score <8 is associated with disability in lower extremity functioning.24