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. 2014 Jan 16;124(2):824–834. doi: 10.1172/JCI68897

Figure 5. Combinatorial targeting of Tie1 and Angpts results in greater inhibition of tumor growth than targeting either alone.

Figure 5

(A) Experimental settings for induction of Tie1 deletion by tamoxifen (TAM) pellets, soluble extracellular domain of murine Tie2 (mTie2-ECD) or soluble murine Fc gamma receptor (mFc) expression, and LLC tumor implantation. (B) LLC tumor growth curves. (C) Tumor volume and weight at 18 days. (D) Vascular area, vessel length, and vessel width (expressed as a percentage of control plus mFc). Error bars denote SEM. *P < 0.05 versus control plus IgG; #P < 0.05 versus control plus mTie2-ECD.