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. 2014 Jan 2;124(2):604–616. doi: 10.1172/JCI71017

Figure 2. Restoration of orexin receptor expression in the DR and LC inhibits cataplexy-like episodes and consolidates wakefulness, respectively.

Figure 2

Control Ox1r–/–Ox2r–/– (n = 16), Ox1r–/–Ox2r–/–+DR-OX2R (n = 7), Ox1r–/–Ox2r–/–+LC-OX1R (n = 8), Ox1r–/–Ox2r–/–+TMN-OX2R (n = 4), Ox1r–/–Ox2r–/–+PPT-OX1R (n = 4), and WT (n = 4) mice were recorded. Mean values of 3 nights’ recordings are shown. Ox1r–/–Ox2r–/– controls were injected with AAV-CAG/EGFP into the DR or LC, AAV-Pet1/ChR2::EYFP into the DR, or AAV-PRSx8/ChR2::EYFP into the LC. (A) Number of and time spent in cataplexy-like episodes. (B) REM sleep latency and time spent in REM sleep. (C) Duration and number of wakefulness episodes during the dark phase. *P < 0.05, **P < 0.01 vs. Ox1r–/–Ox2r–/– control; #P < 0.05, ##P < 0.01 vs. WT. Values are mean ± SEM.