Figure 3. Suppression of narcoleptic symptoms is correlated with the number of serotonergic or noradrenergic neurons with orexin receptor in the DR or LC.

(A) Correlation between number of cataplexy-like episodes and number of EGFP⁺ cells in TPH⁺ DR, TPH^– DR, vlPAG, or the region lateral to the DR and MnR (including the paratrochlear nucleus and pontine reticular nucleus) of Ox1r^–/–Ox2r^–/– +DR-OX2R mice (Successfully targeted) and those with off-target restoration (Unsuccessfully targeted). (B) Correlation between wakefulness episode duration and number of EGFP⁺ cells in TH⁺ LC, TH^– LC, or regions lateral (including PB), medial, or ventral (including SubC) to the LC of Ox1r^–/–Ox2r^–/–+LC-OX1R mice and those with off-target restoration. Pearson r, P values, and regression lines are shown.