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. 2014 Jan 2;124(2):604–616. doi: 10.1172/JCI71017

Figure 6. Pharmacogenetic activation of DR serotonergic and LC noradrenergic neurons suppresses cataplexy-like episodes and consolidates wakefulness, respectively. orexin/ataxin-3 mice with DR serotonergic neuron–selective (A–D; n = 7) or LC noradrenergic neuron–selective (E–H; n = 8) expression of hM3Dq were injected with saline or CNO.

Figure 6

Mean values of 3 nights’ recordings are shown. (A and E) Number of and time spent in cataplexy-like episodes and REM sleep latency. (B and F) Hourly plots of number and total time of cataplexy-like episodes. (C and G) Duration and number of wakefulness episodes within 12 hours after saline or CNO administration at ZT 12 (arrows). (G) Time-weighted frequency histogram of wakefulness duration is also shown (P < 0.001, drug effect and interaction of drug and wakefulness duration, 2-way repeated-measures ANOVA). (D and H) Hourly plots of wakefulness duration and number within 12 hours after administration at ZT 12 (arrows). *P < 0.05, #P < 0.01, 2-tailed Student’s paired t test. Values are mean ± SEM.