Figure 8. UGE.

(A) Time course of UGE during the fasting period (–180 to 0 minutes) and the period after meal ingestion (0 to 300 minutes) in patients with type 2 diabetes during the baseline study, after a single dose (acute study), and after 28 days of empagliflozin dosing (chronic study). Data were averaged over 30-minute time intervals and expressed as grams per hour. Plots represent mean ± SD. (B) The glucose excretion data in A are plotted against the corresponding mean plasma glucose concentration during the corresponding periods of urine collection (n = 66) for the baseline study (blue lines) and the 2 studies after dosing (n = 132); the latter were combined because they were fully overlapping (red lines). The blue lines are the quadratic polynomial fit and its 95% confidence intervals for the baseline data, and the red lines are the linear fit and its 95% confidence interval for the empagliflozin studies. The top x axis indicates HbA_1c levels corresponding to the mean plasma glucose concentrations on the bottom x axis, derived by linear correlation of the entire data set.