Figure 7. Treatment of mice with ABCB8 deletion in the heart leads to exacerbated cardiomyopathy.

(A) Echocardiography images of control (Abcb8^fl/fl) and Abcb8^fl/fl mice crossed with α-MHC-MCM mice (i.e., cs-Abcb8^–/– mice) after treatment with PBS or DOX and treatment with tamoxifen. (B) FS, (C) EF, and (D) LVDd in Abcb8^fl/fl mice or Abcb8^fl/fl mice (fl/fl) crossed with α-MHC-MCM animals (cre,fl/fl) at baseline after treatment with tamoxifen and after treatment with tamoxifen and DOX (n = 4–5). Data are presented as mean ± SEM. *P < 0.05.