Table 1.

Characteristics and phenotypic data for the 100 study subjects.

	Type 3 VWD (n=42)	OC (n=21)	Type 1 VWD (n=30)	UFM (n=7)	p
No. of Females (%)	23 (55)	11 (52)	17 (57)	4 (57)	ns
Mean age, years (range)	29 (1–72)	51 (32–83)	39 (2–85)	49 (22–68)	0.001
No. Blood group O (%)	16 (39)	6 (29)	10 (33)	0 (0)	ns
Mean VWF:Ag, IU/ml (range)	0.02 (0.01–0.07)	0.74 (0.24–1.42)	0.35 (0.11–0.52)	1.40 (0.95–2.04)	<0.001
Mean VWF:RCo, IU/ml (range)	0.02 (0.00–0.05)	0.66 (0.15–1.15)	0.30 (0.05–0.57)	1.04 (0.66–1.96)	<0.001
Mean FVIII:C, IU/ml (range)	0.03 (0.00–0.09)	0.88 (0.37–1.56)	0.53 (0.02–1.32)	1.23 (0.52–2.12)	<0.001
Median bleeding score (range)	13 (3–30)	1 (−1 to 6)	4 (0–12)	0 (−1–4)	<0.001

OC = obligate carrier; UFM = unaffected family member; ns = no significance. One-way ANOVA followed by Tukey’s post hoc testing for all linear variables. For age: post-hoc analysis p=0.001 between type 3 and OC, all other groups =ns. For bleeding score: Kruskal-Wallis followed by Mann-Whitney U post hoc testing Post-hoc testing BS: p<0.001 between UFM and T1, T1 and OC, and between T3 and all other groups. Chi-squared testing for categorical variables.