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. 2013 Nov 5;25(1):83–91. doi: 10.1089/hgtb.2013.089

FIG. 4.

FIG. 4.

The fundi of animals, receiving laser photocoagulation and/or scAAV CMV EGFP vectors, were evaluated for area of fluorescence. The area of fluorescence of each fundus was normalized relative to the total fundus area. The fractional areas of fundus fluorescence were compared between groups. The mean values for this ratio for each capsid type were (laser-untreated, laser-treated) as follows: AAV2: 0.24±0.10, 0.32±0.12; AAV5: 0.21±0.05, 0.26±0.08; and AAV8: 0.17±0.05, 0.31±0.06. There was a statistically significant difference in the AAV5 and AAV8 vector-treated animals (p=0.028) but not in the AAV2 vector-treated animals (p=0.075). The mean values for area ratio for the laser-untreated/vector-uninjected and laser-treated/vector-uninjected eyes were 0.07±0.02 and 0.07±0.03, respectively. (A) Control versus scAAV2-EGFP injected group; (B) control versus scAAV5-EGFP-injected group; (C) control versus scAAV8-EGFP-injected group. *p<0.05, **p>0.05, tested by Wilcoxon signed-rank test.