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. Author manuscript; available in PMC: 2014 May 7.
Published in final edited form as: Nature. 2013 Oct 13;503(7474):141–145. doi: 10.1038/nature12648

Fig. 2. LeuBAT Δ13-sertraline complex adopts an outward-facing open conformation.

Fig. 2

(a) Cross-sections of the crystal structure of Δ13-sertraline showing the solvent accessible surface area (blue). Bound sertraline is shown in yellow sticks. (b-c) Zoom into the sertraline binding pocket viewed within the membrane plane (b) and from the extracellular side (c). Sertraline and key residues in the pocket are depicted in both sticks and spheres showing the van der Waals radius. Salt bridges and hydrogen bonds are in dashed lines. Phe259 in (b) is omitted for clarity.