Table 3.
SNPs identified through Nashville/Marshfield sample GWAS that was replicated in ONTARGET
| Chromosome | SNP | Minor allelea | Cases | Controls | P-value Hardy–Weinberg equilibrium | Odds ratio additive genetic model (95% CI) | P-value | Odds ratio dominant genetic model (95% CI) | P-value | Odds ratio recessive genetic model (95% CI) | P-value | Gene |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10 | rs500766 | PRKCQ | ||||||||||
| Caucasians in the GWAS | T | 0.15 | 0.31 | 0.05 | 0.42 (0.28–0.63) | 2.97E – 05 | 0.42 (0.26–0.67) | 3.04E – 04 | 0.07 (0.01–0.49) | 7.97E – 03 | ||
| ONTARGET | T | 0.42 | 0.54 | 0.65 | 0.56 (0.25–1.25) | 0.16 | 0.28 (0.09–0.89) | 0.03 | 1.11 (0.31–4.01) | 0.87 | ||
| 12 | rs2724635 | ETV6 | ||||||||||
| African Americans in the GWAS | G | 0.72 | 0.50 | 0.75 | 2.78 (1.72–4.00) | 2.73E – 05 | 3.23 (1.75–6.25) | 2.11E – 04 | 5.56 1.85–16.67 | 2.01E – 03 | ||
| ONTARGET | G | 0.63 | 0.46 | 0.50 | 2.02 (0.91–4.48) | 0.09 | 1.70 (0.44–6.52) | 0.44 | 3.27 (1.03–10.35) | 0.04 | ||
CI, confidence interval; ETV6, ETS variant gene 6; GWAS, genome-wide association studies; ONTARGET, Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial.
a
Minor allele based on allele frequencies in the Nashville/Marshfield study.