Table 4.

SNPs identified using the candidate gene approach in ONTARGET

Chromosome	SNP	Allele	Cases	Controls	P-value Hardy–Weinberg equilibrium	Odds ratio additive genetic model (95% CI)	P-value	Odds ratio dominant genetic model (95% CI)	P-value	Odds ratio recessive genetic model (95% CI)	P-value	Gene
3	rs989692	T	0.21	0.09	0.59	2.73 (0.92–8.12)	0.07	4.27 (1.03–17.73)	0.046	3.00 (0.19–47.96)	0.44	MME (neprilysin)
1	rs1924518	A	0.50	0.68	1.00	0.47 (0.22–1.03)	0.06	0.47 (0.12–1.78)	0.27	0.27 (0.07–1.02)	0.05	DENND1B
1	rs2786098	T	0.36	0.57	0.25	0.36 (0.14–0.94)	0.036	0.36 (0.09–1.35)	0.13	0.16 (0.02–1.21)	0.08	CRB1

CI, confidence interval; ONTARGET, Ongoing Telmisartan Alone and in Combination with Ramipril Global Endpoint Trial; SNP, single-nucleotide polymorphism.