Fig. 3.

MRI images of white matter and structural abnormalities associated with FXTAS [1,3,23,30,162]. For each pair of images, a normal control (left) and FXTAS case (right) are represented. The white arrows indicate increased signal intensity on T2 turbo spin-echo sequences in the middle cerebellar peduncle (MCP) (a), sub-insular white matter (c), and cerebral white matter (d). Thinning and increased signal of the trunk and splenium of the corpus callosum (b; arrows) are from the T2 FLAIR sequence. Cases depicted in this figure are males, as follows: (a) 70 yr, FXTAS stage 3, 96 CGG repeats; (b) same as a; (c) 65 yr, stage 3, 91 CGG repeats; (d) 78 yr, stage 4, 116 CGG repeats. The control used for all images and comparisons was a 68-year-old man with 32 CGG repeats. Images kindly provided by Patrick Adams.