TABLE 3.
CSF biomarkers and ApoE in normal population, a summary of findings.
| First author, year | ApoE4+ (n) | ApoE4− (n) | Results | |
|---|---|---|---|---|
| De Meyer 2010 [116] | 8 | 65 | individuals with AD-like CSF profile were seven times more likely to carry an ApoE4 allele. |
|
| Fagan 2000 [119] | 12 | 13 | higher Aß40/Aß42 in ApoE4+ than ApoE4− subjects | |
| Fjell 2010 [115] | 21 | 37 | lower Aß42 in ApoE4+ than ApoE4− subjects a trend towards higher t-tau and p-tau in ApoE4+ subjects |
|
| Glodzik-Sobanska 2009 [74] |
30 | 48 | higher t-tau in ApoE4+ than ApoE4− subjects higher p-tau231 in ApoE4+ than ApoE4− subjects a steeper increase in p-tau 231 with age in ApoE4+ subjects |
|
| Golombowski 1997 [138] | 3 | 9 | higher t-tau in ApoE4+ than ApoE4− subjects | |
| Herukka 2007 [106] | 62 | 76 | lower Aß42 in ApoE4+ than ApoE4− subjects higher t-tau in ApoE4+ than ApoE4− subjects higher p-tau in ApoE4+ than ApoE4− subjects |
|
| Kester 2009 [107] | 63 | 111 | lower Aß42 in ApoE4+ than ApoE4− subjects higher t-tau in ApoE4+ than ApoE4− subjects a trend towards higher p-tau in ApoE4+ subjects |
|
| Lo 2011 [98] | 61 | 168 | ApoE4 status did not modify the rate of Aß42 change. | |
| Mulder 2010 [113] | 3 | 8 | ApoE4+ group had a higher proportion of individuals with AD-like CSF profile |
|
| Peskind 2006 [73] | 184 total, n in groups not given |
ApoE4+ subjects showed sharp decline in Aß42 in their 60s, while ApoE4− showed significantly less change. |
||
| Popp 2010 [112] | 64 | 216 | lower Aß42 in ApoE4+ than ApoE4− subjects no difference in p-tau181 |
|
| Prince 2004 [117] | 32 | 86 | lower Aß42 in ApoE4+ than ApoE4− subjects | |
| Smach 2008 [110] | 9 | 44 | lower Aß42 in ApoE4+ than ApoE4− subjects in tau | no difference |
| Stenset 2006 [109] | 77 | 46 | lower Aß42 in ApoE4+ than ApoE4− subjects | |
| Stomrud 2010 [118] | 10 | 27 | ApoE4+ subjects have greater longitudinal decreases in Aß42 and higher t-tau at follow-up |
|
| Sunderland 2004 [108] | 57 | 85 | lower Aß42 in ApoE4+ than ApoE4− subjects in tau | no difference |
| Tapiola 2000 [111] | 13 | 25 | lower Aß42 in ApoE4+ than ApoE4− subjects higher t-tau in ApoE4+ than ApoE4− subjects |
|
| Vemuri 2010 [114] | 27 | 82 | lower Aß42 in ApoE4+ than ApoE4− subjects in tau | no difference |
| Vemuri 2010a [122] | 22 | 70 | ApoE4 status did not modify the annual rate of Aß42 or t-tau change. | |