Table 5.
Annual rate of change in CDR-SB and MMSE according to preclinical AD stage
| Stages | Slope CDR-SB | P-value slope | Difference compared to other groups |
Slope MMSE | P-value slope | Difference compared to other groups |
|---|---|---|---|---|---|---|
| Normal group | 0·03 (0·03) | P=0·2784 | 1: p=0·0289 | −0·01 (0·03) | P=06955 | 1: p=0·2324 |
| 2: p<0·0001 | 2: p=0·0021 | |||||
| 3: p=0·0009 | 3: p=0·0233 | |||||
| S: p=0·3870 | S: p=09857 | |||||
| Stage 1 | 0·15 (0·04) | P=0·0014 | 2: p=0·0638 | −0·09 (0·05) | P=0·0966 | 2: p=0·0655 |
| 3: p=0·0373 | 3: p=0·1019 | |||||
| S: p=0·2096 | S: p=02925 | |||||
| Stage 2 | 0·28 (0·05) | P<0·0001 | 1: p=0·0638 | −0·24 (0·06) | P=0·0003 | 1: p=0·0655 |
| 3: p=03848 | 3: p=0·6227 | |||||
| S: p=0·0021 | S: p=0·0047 | |||||
| Stage 3 | 0·37 (0·10) | P=0·0002 | 1: p=0·0373 | −0·31 (0·12) | P=0·0145 | 1: p=0·1019 |
| 2: p=03848 | 2: p=0·6227 | |||||
| S: p=0·0048 | S: p=0·0279 | |||||
| SNAP group | 0·07 (0·04) | P=0·0685 | 1: p=0·2096 | −0·01 (0·04) | P=0·7578 | 1: p=0·2925 |
| 2: p=0·0021 | 2: p=0·0047 | |||||
| 3: p=0·0048 | 3: p=0·0279 |
Data are slopes (SE) corrected for age, gender, education, and APOE genotype and comparison to other groups. AD=Alzheimer’s disease, CDR-SB=Clinical Dementia Rating scale Sum of Boxes(range 0–18, with 0 as the best score), MMSE=Mini Mental State Examination(range 0–30, with 30 as the best score), SNAP=Suspected Non-Alzheimer Pathophysiology. N=normal group, 1=stage 1, 2=stage 2, 3=stage 3, S=SNAP group.