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. Author manuscript; available in PMC: 2014 Jan 28.
Published in final edited form as: Curr Top Dev Biol. 2003;57:1–44. doi: 10.1016/s0070-2153(03)57001-6

Figure 6.

Figure 6

The effect of loss of both Ngn1 and Math1 on ear development and development of hair cell precursors is shown in three littermates. Note the absence of all sensory neurons and the reduction in size of the saccule and the cochlea in Ngn1 null mice (A, B). Combining Ngn1 null with Math1 null (C) is a simple combination of the Ngn1 phenotype (reduction in cochlea and saccule) with the Math1 null phenotype (absence of BDNF–LacZ-positive cells in the utricle, saccule, and basal turn of the cochlea). In contrast, the apex and the three canal cristae show BDNF–LacZ-positive cells even in the double-null mutants. Bar indicates 100 μm.