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. Author manuscript; available in PMC: 2014 Jan 28.
Published in final edited form as: Curr Top Dev Biol. 2003;57:1–44. doi: 10.1016/s0070-2153(03)57001-6

Figure 9.

Figure 9

The effects of neurotrophin and neurotrophin receptor null mutations on the pattern of cochlear innervation is shown. Note the severe reduction in density of cochlear innervation in a pair of neurotrophin ligand (NT-3) and neurotrophin receptor(trkC) null mutants (B, C). In addition, there is a complete loss of all sensory neurons in the basal tip (Base) of either neurotrophin or neurotrophin receptor null mutant (compare A with B, C). A Ntf3 null mutation combined with Ntrk3 heterozygosity (designated as TrkC−/−/TrkB+/−) results in further loss of innervation and a patchy distribution of the remaining sensory neurons (D). Note that afferents from middle turn spiral sensory neurons (Spgl) expand along inner hair cells (shown as a DIC image) to reach the base. Bar indicates 1 mm.