Table 2.

Run 1 brain activation to cannabis cues>Gaussian baseline: correlation with cannabis craving

				MNI Coordinates					Correlation Coefficients
Cluster #	Side	Regions	Brodmann’s Area	x	y	z	ES	Pre- Run	Run 1	Run 2	Run 3
	Cannabis greater than baseline
1	R	Posterior cingulate	29	4	48	6	2.91	0.399	0.432	0.341	0.311
2	L	Posterior cingulate, precuneus	29, 30, 23	−4	−50	8	3.13	0.442	0.462	0.418	0.396
3	R + L	Occipital cortex (including calcarine, lingual, cuneus),	17–20, 23, 27–28, 34–37, 39	−8	−94	−2	9.72	0.431	0.285	0.471	0.530
		fusiform gyrus, parahippocampal gyrus, hippocampus, amygdala
4	R	Parahippocampal gyrus; thalamus; hippocampus	27, 35	18	−32	−4	2.75	0.487	0.494	0.456	0.511
5	R	Parahippocampal gyrus, including amygdala; hippocampus	34	16	−2	−18	2.87	0.346	0.321	0.368	0.427
6	L	Hippocampus		−28	−32	−8	4.14	0.568	0.518	0.535	0.552
7	L	Superior temporal pole	38, 28	−28	12	−30	3.00	0.512	0.529	0.509	0.572
8	L	Middle temporal pole	21, 38	−40	12	−34	3.51	0.046	0.065	0.006	0.082
9	R	Middle occipital gyrus	19	30	−90	16	4.91	0.484	0.300	0.488	0.514
10	R	Middle occipital gyrus; middle temporal gyrus	19, 18, 39	28	−94	4	5.80	0.305	0.144	0.365	0.418
11	L	Middle occipital gyrus	19	−32	−90	16	5.69	0.378	0.221	0.412	0.434
12	R	Superior frontal gyrus	9, 10	2	62	0	3.29	0.152	0.174	0.094	0.138
13	L	Superior frontal gyrus	9	−10	58	34	2.78	0.231	0.153	0.203	0.202
14	L	Medial frontal gyrus	10	−4	62	2	2.76	0.362	0.415	0.294	0.296
15	L	Inferior orbitofrontal	47, 11	−30	30	−20	4.32	0.369	0.368	0.379	0.368
	Cannabis less than baseline
16	R	Inferior parietal; supramarginal gyrus; angular gyrus	40	56	46	46	3.57	0.081	0.176	0.091	0.202
17	L	Insula; superior temporal gyrus	22	48	16	6	2.89	0.015	0.041	0.029	−0.025
18	R	Superior temporal	42, 41	64	22	10	2.34	0.353	0.321	0.368	0.402
19	L	Superior temporal	41	46	36	12	2.56	−0.088	0.021	0.115	−0.035

Statistical Parametric Analysis (SPM) was performed using a 1-sample t-test for all subjects across all runs with the contrast of activation during cannabis cues versus baseline activation (n=16). Voxel threshold p=0.001, extent threshold k=30, family-wise corrected p= 0.05. Montreal Neurological Institute (MNI) coordinates and effect size (ES; Cohen’s d) correspond to peak voxel in each region. Bold font indicates that BOLD signal intensity (as the measure of activation) in this region was found to be correlated with craving at the threshold of p≤0.05.