Table 3.

Run 1 brain activation to cannabis cues>nature cues: correlation with cannabis craving

				MNI Coordinates					Correlation Coefficients
Clus ter #	Side	Regions	Brodmann’s Area	x	y	z	ES	Pre- Run	Run 1	Run 2	Run 3
	Cannabis greater than nature
1	R	Inferior occipital gyrus	18, 19	42	−74	−8	4.64	−0.196	−0.262	−0.209	−0.275
2	L	Fusiform gyrus (inferior occipital gyrus, middle occipital gyrus, middle temporal gyrus, cerebellum crus1, cerebellum)	18, 19, 20, 37	−40	−42	−22	4.21	−0.177	−0.218	−0.133	−0.146
3	L	Inferior occipital gyrus (lingual gyrus, fusiform gyrus)	18, 19	−42	−74	−8	4.15	−0.004	−0.085	−0.021	−0.093
4	R	Fusiform gyrus (middle temporal gyrus, inferior temporal gyrus, inferior occipital gyrus)	18, 19, 37, 39	42	−68	−18	4.07	−0.118	−0.237	−0.043	−0.065
5	L	Hippocampus (amygdala, uncus)	34	−20	−6	−20	2.63	0.001	0.071	−0.015	0.085

Statistical Parametric Analysis (SPM) was performed using a 1-sample t-test for all subjects across all runs with the contrast of activation during cannabis cues > activation during nature images (n=16). Voxel threshold p=0.001, extent threshold k=30, family-wise corrected p= 0.05. Montreal Neurological Institute (MNI) coordinates and effect size (ES; Cohen’s d) correspond to peak voxel in each region. BOLD signal intensity (as the measure of activation) was extracted from activated regions for all runs. Only the correlation of Run 1 BOLD signal intensity with craving score is shown. There were no regions in which BOLD signal intensity was found to be correlated with craving at the threshold of p≤0.05.