Table 4.

Run 1 brain activation to cannabis cues>food cues: correlation with cannabis craving

				MNI Coordinates					Correlation Coefficients
Clus ter #	Side	Regions	Brodmann’s Area	x	y	z	ES	Pre- Run	Run 1	Run 2	Run 3
	Cannabis greater than food
1	R	Medial orbital frontal gyrus	10, 11	6	58	−6	3.72	0.702	0.674	0.715	0.790
2	R	Middle temporal gyrus (superior temporal gyrus, middle occipital gyrus, inferior temporal gyrus)	19, 22, 37, 39	54	−64	12	3.28	0.019	0.171	−0.106	0.003
3	L	Inferior temporal gyrus (fusiform gyrus)	19, 20	−46	−46	−24	3.16	−0.414	−0.312	−0.491	−0.396
4	L	Middle occipital gyrus (middle temporal gyrus, inferior temporal gyrus)	19, 22, 37, 39	−44	−82	4	2.87	−0.026	0.106	−0.129	0.034
5	R	Fusiform gyrus (inferior temporal gyrus)	37	40	−50	−22	2.76	−0.474	−0.441	−0.465	−0.444

Statistical Parametric Analysis (SPM) was performed using a 1-sample t-test for all subjects across all runs with the contrast of activation during cannabis cues>activation during food images (n=16). Voxel threshold p=0.001, extent threshold k=30, family-wise corrected p= 0.05. BOLD signal intensity (as the measure of activation) was extracted from activated regions for all runs. Montreal Neurological Institute (MNI) coordinates and effect size (ES; Cohen’s d) correspond to peak voxel in each region.