. Author manuscript; available in PMC: 2014 Jan 28.

Published in final edited form as: J Clin Pharmacol. 2011 Mar 21;51(8):1186–1194. doi: 10.1177/0091270010379810

Table 2.

Comparison of Sodium 2,2 Dimethylbutyrate Administered under Fasted and Non-Fasting Conditions. Studies were performed at the 20 mg/kg dose level.

Dependent Variable	Mean			F_rel %	p-value
Dependent Variable	Fasting	Nonfasting	Difference	F_rel %	p-value
C_max (μg/mL)	88.92	60.40	28.52	67.9	0.0037
AUC_(0-last) h•μg/mL	1174	1162	12.10	99.0	0.8559
AUC _(0-∞) h•μg/mL	1190	1186	3.267	99.7	0.9638
T_max	0.750	4.50	−3.75	NC	0.0355

Abbreviations: CI: confidence interval; F_rel: relative bioavailability; NC: not calculated; SD: standard deviation