FIG. 1.

Comparison of original and K137R mutants of AAV7-, AAV8-, and AAV9-cmv-LacZnls vectors in ICR mice via LacZ staining. About 5×10¹¹ vg of AAV vectors were delivered into 1-month-old ICR male mice via tail vein injection, and the mice were euthanized 2 weeks postinjection (n=5 for each group). (a) LacZ staining of liver tissue. The nucleus LacZ was stained blue (scale bar: 100 μm). (b) LacZ staining of heart. (c) LacZ staining of muscle. AAV, adeno-associated virus. Color images available online at www.liebertpub.com/hgtb