Table 4.
Multivariable Association Between Kidney Function and Hospitalization From Any Cause Among 24 331 Adults With Heart Failure Stratified by Preserved and Reduced Left Ventricular Systolic Function (2005–2008)
| Hospitalization From Any Cause Adjusted Hazard Ratio (95% Confidence Interval)
|
||
|---|---|---|
| Preserved Systolic Function* (n=14 579) | Reduced Systolic Function† (n=9752) | |
| eGFR (mL/min per 1.73 m2) category, n (%) | ||
| 90–130 | 1.15 (1.05–1.25) | 1.04 (0.94–1.16) |
| 60–89 | Reference | Reference |
| 45–59 | 1.08 (1.02–1.13) | 1.07 (1.01–1.14) |
| 30–44 | 1.16 (1.09–1.22) | 1.09 (1.02–1.17) |
| 15–29 | 1.32 (1.24–1.41) | 1.47 (1.35–1.60) |
| <15 | 1.73 (1.50–2.00) | 1.85 (1.52–2.25) |
| Dialysis | 1.87 (1.71–2.04) | 1.71 (1.53–1.92) |
| Urine dipstick protein excretion | ||
| Negative/trace or undocumented | Reference | Reference |
| 1+ | 1.28 (1.22–1.34) | 1.30 (1.23–1.38) |
| 2+ | 1.33 (1.26–1.40) | 1.37 (1.27–1.48) |
| 3+ | 1.36 (1.26–1.47) | 1.42 (1.27–1.57) |
eGFR indicates estimated glomerular filtration rate.
Adjusted for age, sex, prevalent heart failure, acute myocardial infarction, unstable angina, percutaneous coronary intervention, ischemic stroke or transient ischemic attack, atrial fibrillation or flutter, mitral or aortic valve disease, peripheral arterial disease, pacemaker, dyslipidemia, hypertension, diabetes mellitus, hospitalized bleeds, diagnosed depression, chronic lung disease, mechanical fall, hemoglobin, systolic blood pressure, high-density lipoprotein cholesterol, year of study entry, and sites.
Adjusted for age, sex, prevalent heart failure, acute myocardial infarction, unstable angina, percutaneous coronary intervention, ischemic stroke or transient ischemic attack, other thromboembolic event, atrial fibrillation or flutter, ventricular tachycardia or fibrillation, mitral or aortic valve disease, peripheral arterial disease, pacemaker, cardiac resynchronization therapy, implantable cardioverter defibrillator, dyslipidemia, hypertension, diabetes mellitus, hospitalized bleeds, diagnosed depression, chronic lung disease, mechanical fall, hemoglobin, systolic blood pressure, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, year of study entry, and sites.