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Mitoxantrone (MIT) retention in anacardic acid (AA) liposomes (♦) at pH 5.0 (continuous line) and pH 7.4 (dashed line) and in cholesterol liposomes at pH 5.0 (⋄, continuous line). The difference between AA liposomes at pH 5.0 and 7.4 is statistically significant from 3 hours onwards.
