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. 2014 Jan 28;9(1):e85940. doi: 10.1371/journal.pone.0085940

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) YU2 gp120 coreV3s (surface representation in grey) in complex with NBD-557 (stick representation in green) and Fab 48d depicted in a ribbon diagram (light chain in light blue and heavy chain in blue). (B) NBD-557 (stick representation in cyan) binds the Phe 43_CD4 cavity on clade A/E_93TH057 gp120 core_e. Area colored red represents N-terminal residues (44–89), which are missing in gp120 core in (A). CD4 footprints on gp120 are colored in yellow in (A) and (B). (C) Superposition of NBD-557- and Fab 48d- bound YU2 gp120, NBD-557-bound clade A/E_93TH057 gp120 core, and the CD4-bound gp120. Two NBD-557 (green and cyan) and the side chain of Phe 43_CD4 (yellow) in the cavity are highlighted.