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. 2014 Jan 28;9(1):e85940. doi: 10.1371/journal.pone.0085940

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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(A) Clade B_YU2 gp120 core_e binds both NBD-556(Ligand:1) and sCD4. Ser 375 was shown in the NBD-557 bound cavity. (B) Clade A/E_93TH057 gp120 core_e does not show detectable binding to NBD-556 immobilized onto a CM5, but binds to sCD4. NBD-557 modeled into the Phe 43 cavity of clade A/E gp120 clashes with His 375. (C) Clade A_KER2008 gp120 core_e does not bind NBD-556, but does bind sCD4. Met 375 modeled into NBD-557-bound YU2 gp120 clashes with NBD-557. (D) Clade CRF34_1_OUR2478P gp120 core_e does not bind NBD-556, but binds sCD4. NBD-557 clashes with Trp 375 in the Phe 43 cavity.