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. 2014 Jan 28;9(1):e85828. doi: 10.1371/journal.pone.0085828

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© 2014 de Santos-Sierra et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) Schematic representation of how cells get connected. At DIV 0, 4 cells of radius are located at random positions. The first iteration of the algorithm, DIV 1, assigns to each cell a disk of radius (green shade). At the next iteration, DIV 2, the disk's growth rate decreases, , and a link between two cells is established when their disks intersect (DIV 3). This process continues until steps. (B) Force diagram explaining cell migration and clustering. Tension forces , , and are acting on the central cluster composed of two cells, whose vector sum (red arrow) exceeds the adhesion to the substrate (green arrow). As a result, a new equilibrium state is produced with new tension forces , , and , being the central cluster pulled in the direction of the net force approaching the largest cluster.

Inline graphic — (A) Schematic representation of how cells get connected. At DIV 0, 4 cells of radius are located at random positions. The first iteration of the algorithm, DIV 1, assigns to each cell a disk of radius (green shade). At the next iteration, DIV 2, the disk's growth rate decreases, , and a link between two cells is established when their disks intersect (DIV 3). This process continues until steps. (B) Force diagram explaining cell migration and clustering. Tension forces , , and are acting on the central cluster composed of two cells, whose vector sum (red arrow) exceeds the adhesion to the substrate (green arrow). As a result, a new equilibrium state is produced with new tension forces , , and , being the central cluster pulled in the direction of the net force approaching the largest cluster.