Table 1. Physiological effects in C57BL/6 and KKAy mice 4 weeks after nitrosonifedipine (NO-NIF) administration.

NO-NIF	C57BL/6		KKAy
	−	+	−	+
Body weight (g)	28.1±0.6	27.7±0.4	49.7±0.9*	47.6±0.6*
Fasting plasma glucose (mg/dL)	95.8±5.4	99.3±7.8	120.8±9.0*	120.0±11.8*
Systolic blood pressure (mmHg)	94.4±2.5	96.0±2.6	111.1±2.3*	108.3±3.3*
White adipose tissue weight (g)	0.8±0.1	0.6±0.1	1.9±0.1*	1.7±0.1*
Kidney weight (g)	360.8±9.2	374.5±11.1	645.9±20.5*	614.0±21.1*
Serum creatinine (mg/dL)	0.112±0.005	0.103±0.005	0.091±0.004	0.090±0.005
Urine volume (mL)	0.8±0.1	0.9±0.2	7.4±1.3*	3.7±0.5*#
Daily water intake (mL/day)	10.3±1.6	10.2±1.4	20.2±1.8*	18.2±1.4*

Values are expressed as mean ± SEM, n = 8–10. *p<0.05 vs. vehicle-treated C57BL/6 mice, #p<0.05 vs. vehicle-treated KKAy mice.