Table 3. Frequency of FoxO1 and FoxO3 polymorphism in CHD from two different populations.
Subjects from Population 1 | Subjects from Population 2 | Combined subjects | ||||||||
SNP | genotype | CHD | Non-CHD | P | CHD | Non-CHD | P | CHD | Non-CHD | P |
rs2755209 | CC | 403 | 423 | 0.269 | 221 | 223 | 0.836 | 624 | 646 | 0.234 |
CA | 319 | 301 | 209 | 199 | 528 | 500 | ||||
AA | 86 | 105 | 33 | 36 | 119 | 141 | ||||
Allelic A frequency | 0.304 | 0.308 | 0.297 | 0.296 | 0.301 | 0.303 | ||||
rs2721072 | AA | 360 | 399 | 0.285 | 219 | 207 | 0.245 | 579 | 606 | 0.263 |
AG | 342 | 336 | 179 | 199 | 521 | 535 | ||||
GG | 106 | 94 | 65 | 52 | 171 | 146 | ||||
Allelic G frequency | 0.343 | 0.316 | 0.334 | 0.331 | 0.339 | 0.321 | ||||
rs4325427 | TT | 378 | 392 | 0.393 | 226 | 220 | 0.759 | 604 | 612 | 0.322 |
TC | 326 | 348 | 185 | 192 | 511 | 540 | ||||
CC | 104 | 89 | 52 | 46 | 156 | 135 | ||||
Allelic C frequency | 0.330 | 0.317 | 0.312 | 0.310 | 0.324 | 0.325 | ||||
rs17592371 | CC | 380 | 387 | 0.986 | 218 | 202 | 0.651 | 598 | 589 | 0.794 |
CT | 297 | 308 | 181 | 191 | 478 | 499 | ||||
TT | 131 | 134 | 64 | 65 | 195 | 199 | ||||
Allelic T frequency | 0.346 | 0.347 | 0.334 | 0.350 | 0.341 | 0.348 | ||||
rs768023 | AA | 579 | 565 | 0.087 | 307 | 301 | 0.937 | 886 | 866 | 0.243 |
AG | 176 | 218 | 136 | 135 | 312 | 353 | ||||
GG | 53 | 46 | 20 | 22 | 73 | 68 | ||||
Allelic G frequency | 0.175 | 0.187 | 0.190 | 0.195 | 0.180 | 0.189 | ||||
rs1268165 | TT | 484 | 515 | 0.424 | 301 | 302 | 0.526 | 785 | 817 | 0.247 |
TC | 296 | 280 | 142 | 130 | 438 | 410 | ||||
CC | 28 | 34 | 20 | 26 | 48 | 60 | ||||
Allelic C frequency | 0.218 | 0.210 | 0.197 | 0.199 | 0.210 | 0.206 |
Calculations are performed with comparison of three different genotypes. Values are the number of subjects. No significant difference (chi-square test) was found in the frequency of either polymorphism between CHD cases and non-CHD controls.