Table 1. The percentage of non-susceptibility (NS) for the most commonly isolated uropathogens separately, and the probability of inadequate coverage (e.g., weighted average) for uropathogens combined, ISIS-AR, the Netherlands 2012.
| Table 1a. All uropathogens | AMX | AMC | CXM | CAZ | CTX/CRO | 3GC | CARB | CIP | SXT | NIT# | GEN | AMO+GEN | AMC+ GEN | CXM+ GEN | 3GC+GEN |
| %NS | %NS | %NS | %NS | %NS | %NS | %NS | %NS | %NS | %NS | %NS | %NS | %NS | %NS | %NS | |
| E. coli | 46.8 | 18.1 | 12.6 | 4.9 | 5.8 | 6.3 | 0 | 17.2 | 28.4 | 2.5 | 6.0 | 5.0 | 2.8 | 2.4 | 1.6 |
| Enterococcus spp. | 16.7 | 16.7 | IR | IR | IR | IR | 24.4 | NA | 94.1 | 13.4 | LLR | 16.7 | 16.7 | IR | IR |
| P. mirabilis? | 22.2 | 10.7 | 1.3 | 1 | 0.9 | 1.3 | 0.1 | 10.6 | 30.4 | IR | 8.2 | 4.1 | 2.2 | 0.2 | 0.1 |
| K. pneumoniae | IR | 11.5 | 14.6 | 7.4 | 7.9 | 8.4 | 0.2 | 10.8 | 17.3 | 33.0 | 4.7 | 4.7 | 3.7 | 3.9 | 3.9 |
| P. aeruginosa | IR | IR | IR | 4 | IR | IR | 4.9 | 13.1 | IR | IR | 5.0 | 5.0 | 5.0 | 5.0 | 5.0 |
| beta-haemolytic streptococci | 0 | 0 | 0 | NA | 0.5 | 0.5 | 0 | NA | 18.3 | 3.6 | NA | 0 | 0 | 0 | 0 |
| S. aureus | 74.9 | 2.5 | 2.5 | IR | 2.5 | IR | 3.2 | 22.6 | 4.8 | 11 | 1.3 | 1.3 | 0.8 | 0.7 | 0.9 |
| K. oxytoca | IR | 11 | 13.2 | 1.7 | 2.8 | 3 | 0.2 | 4 | 4 | 5.1 | 1.3 | 1.3 | 1.9 | 1.2 | 0.7 |
| E. cloacae | IR | IR | IR | 13.5 | 26.2 | 26.9 | 0.7 | 8.9 | 10.6 | 21.8 | 7.9 | 7.9 | 7.9 | 7.9 | 7.0 |
| M. morganii? | IR | IR | IR | 15.3 | 20.4 | 22.1 | 0 | 13.8 | 17.7 | 70.6 | 8.6 | 8.6 | 8.6 | 8.6 | 2.2 |
| Weighted average* | 43.0 | 20.7 | 29.9 | 10.5 | 23.9 | 26.8 | 2.2 | 11.0 | 28.3 | 19.0 | 4.2 | 3.8 | 2.9 | 16.7 | 16.3 |
| Table 1b. Gram-negative uropathogens only | AMX | AMC | CXM | CAZ | CTX/CRO | 3GC | CARB | CIP | SXT | NIT# | GEN | AMO+GEN | AMC+GEN | CXM+GEN | 3GC+GEN |
| Weighted average* | 53.0 | 25.7 | 21.3 | 5.1 | 12.7 | 13.2 | 0.4 | 14.8 | 26.0 | 23.7 | 5.9 | 4.0 | 2.7 | 2.3 | 1.7 |
IR = intrinsic resistant, NA = not available, LLR = low level resistance.
We only included resistance to meropenem for this bacterium.
For Enterobacteriaceae the breakpoint for E. coli was used.
The distribution of species (e.g., number of isolates of each species) was taken into account when calculating the probability of inadequate coverage (e.g., weighted average); the overall resistance percentages are therefore the resistance percentages that would be encountered when choosing empirical treatment.
AMX: amoxicillin, AMC: amoxicillin-clavulanic acid, CXM: cefuroxime, CAZ: ceftazidime, CTX: cefotaxime, CRO: ceftriaxone, 3GC: 3rd generation cephalosporins, CARB: carbapenems, CIP: ciprofloxacin, SXT: trimethoprim-sulphamethoxazole, NIT: nitrofurantoin, GEN: gentamicin.