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. Author manuscript; available in PMC: 2014 Dec 26.
Published in final edited form as: Cell Rep. 2013 Dec 12;5(6):1600–1610. doi: 10.1016/j.celrep.2013.11.018

Figure 2. Effects of daf-2 rsks-1 on development, reproduction, stress resistance and dietary restriction.

Figure 2

(A) rsks-1 did not affect daf-2 dauer formation at 22.5°C. ns, not significant. (B) daf-2 rsks-1 animals showed delayed, prolonged and overall reduced reproduction. (C) daf-2 rsks-1 animals were more sensitive to heat stress (35°C) than daf-2 (log-rank, p < 0.0001). (D) daf-2 rsks-1 animals were more resistant to oxidative stress by paraquat compared to daf-2 (**, p < 0.01, t - test). (E) daf-2 rsks-1 animals were more resistant to UV stress (2,000 J/m2) than daf-2 (log-rank, p < 0.0001). (F) daf-2 rsks-1 animals showed significantly increased survival under DR by bacterial food deprivation compared to daf-2 (log-rank, p < 0.0001).