Skip to main content
. Author manuscript; available in PMC: 2014 Dec 26.
Published in final edited form as: Cell Rep. 2013 Dec 12;5(6):1600–1610. doi: 10.1016/j.celrep.2013.11.018

Figure 5. Germline signaling modulates the daf-2 rsks-1-mediated synergistic lifespan extension through AMPK and DAF-16.

Figure 5

(A) The glp-1(gf) mutation suppressed the synergistic longevity by daf-2 rsks-1. rsks-1-mediated lifespan extension in daf-2 (daf-2 vs. daf-2 rsks-1): 86% [without glp-1(gf)], 14% [with glp-1(gf)]. (B) The glp-1(gf) mutation decreased phosphorylation of AAK-2 in daf-2 rsks-1. (C) The glp-1(gf) mutation suppressed the significantly increased DAF-16 transcriptional activity in daf-2 rsks-1. ***, p < 0.001. (D) Inhibition of DAF-12 or KRI-1, essential mediators of the germline signaling, significantly suppressed the synergistic longevity by daf-2 rsks-1 (log-rank, p < 0.0001). Quantitative data and statistical analyses are included in Table S1.