Table 2. Summary of the variations from NAc metabolites in mice.
| Metabolitesa | Chemicalshift (ppm) | Control vs. 20 mg/kgcocaine | Control vs. nicotine+2 mg/kg cocaine | 2 mg/kg cocaine vs.nicotine +2 mg/kg cocaine | Control vs.2 mg/kg cocaine | ||||
| VIPb | Loadingc | VIPb | Loadingc | VIPb | Loadingc | VIPb | Loadingc | ||
| Glutamate | 3.72 | 14.95 | +0.728 | 14.91 | +0.715 | 15.19 | +0.726 | 1.16 | +0.057 |
| Glutamate | 3.74 | 10.23 | +0.498 | 9.45 | +0.453 | 9.57 | +0.457 | / | / |
| Tryptamine | 7.70 | 4.54 | +0.171 | 2.05 | −0.098 | 4.52 | +0.216 | 9.55 | −0.487 |
| Tryptamine | 7.68 | 2.99 | +0.112 | 1.43 | −0.068 | 3.64 | +0.174 | 7.34 | −0.374 |
| Glucose | 3.76 | 2.41 | +0.117 | / | / | / | / | 1.99 | −0.102 |
| Lactate | 1.34 | 2.05 | −0.089 | 1.23 | −0.059 | 5.26 | −0.249 | 6.48 | +0.288 |
| * | 3.66 | 1.92 | +0.094 | 2.66 | +0.128 | 1.73 | +0.083 | 1.84 | +0.081 |
| Acetylcholine | 3.24 | 1.83 | −0.089 | / | / | / | / | 3.32 | −0.159 |
| 1-Methylhistidine | 3.70 | 1.57 | +0.076 | 1.51 | +0.073 | 1.52 | +0.072 | 1.02 | +0.014 |
| L-glutamine | 2.14 | 1.45 | −0.071 | 2.37 | −0.113 | / | / | 2.28 | −0.114 |
| L-methionine | 2.16 | 1.37 | −0.065 | 2.38 | −0.114 | / | / | 2.75 | −0.139 |
| Creatine | 3.04 | 1.27 | −0.062 | 1.38 | −0.065 | 2.37 | −0.113 | 1.29 | +0.066 |
| α-Ketogultaric acid | 2.48 | 1.14 | −0.055 | 1.47 | −0.071 | / | / | 1.96 | −0.09 |
| 1-Methylhistidine | 3.68 | 1.08 | +0.052 | / | / | / | / | / | / |
| α-Ketogultaric acid | 2.46 | 1.07 | −0.051 | 1.53 | −0.073 | / | / | 2.05 | −0.099 |
| * | 3.56 | 1.06 | −0.051 | / | / | / | / | 1.01 | +0.012 |
| Phosphocholine | 3.22 | 1.03 | −0.048 | / | / | / | / | 1.22 | +0.049 |
| Proline | 4.12 | 1.01 | +0.047 | 1.24 | +0.058 | 1.68 | −0.08 | 4.15 | +0.211 |
a
Metabolites: (*) represents a material which has not been identified.
b
Variable importance in the projection (VIP≥1) was obtained from OSC-PLS. Oblique line (/) represents no variations of the metabolite between the left group of the subtitle and the right group of the subtitle.
c
Loading: the positive (+) value represents an increase of the metabolite in the right group of the subtitle (e.g.: 20 mg/kg cocaine group of control vs. 20 mg/kg cocaine); while the negative (−) value represents a decrease of the metabolite in the right group of the subtitle; Oblique line (/) represents no variations of the metabolite between the left group of the subtitle and the right group of the subtitle.