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. 2014 Jan 28;9(1):e87040. doi: 10.1371/journal.pone.0087040

Table 2. Summary of the variations from NAc metabolites in mice.

Metabolitesa Chemicalshift (ppm) Control vs. 20 mg/kgcocaine Control vs. nicotine+2 mg/kg cocaine 2 mg/kg cocaine vs.nicotine +2 mg/kg cocaine Control vs.2 mg/kg cocaine
VIPb Loadingc VIPb Loadingc VIPb Loadingc VIPb Loadingc
Glutamate 3.72 14.95 +0.728 14.91 +0.715 15.19 +0.726 1.16 +0.057
Glutamate 3.74 10.23 +0.498 9.45 +0.453 9.57 +0.457 / /
Tryptamine 7.70 4.54 +0.171 2.05 −0.098 4.52 +0.216 9.55 −0.487
Tryptamine 7.68 2.99 +0.112 1.43 −0.068 3.64 +0.174 7.34 −0.374
Glucose 3.76 2.41 +0.117 / / / / 1.99 −0.102
Lactate 1.34 2.05 −0.089 1.23 −0.059 5.26 −0.249 6.48 +0.288
* 3.66 1.92 +0.094 2.66 +0.128 1.73 +0.083 1.84 +0.081
Acetylcholine 3.24 1.83 −0.089 / / / / 3.32 −0.159
1-Methylhistidine 3.70 1.57 +0.076 1.51 +0.073 1.52 +0.072 1.02 +0.014
L-glutamine 2.14 1.45 −0.071 2.37 −0.113 / / 2.28 −0.114
L-methionine 2.16 1.37 −0.065 2.38 −0.114 / / 2.75 −0.139
Creatine 3.04 1.27 −0.062 1.38 −0.065 2.37 −0.113 1.29 +0.066
α-Ketogultaric acid 2.48 1.14 −0.055 1.47 −0.071 / / 1.96 −0.09
1-Methylhistidine 3.68 1.08 +0.052 / / / / / /
α-Ketogultaric acid 2.46 1.07 −0.051 1.53 −0.073 / / 2.05 −0.099
* 3.56 1.06 −0.051 / / / / 1.01 +0.012
Phosphocholine 3.22 1.03 −0.048 / / / / 1.22 +0.049
Proline 4.12 1.01 +0.047 1.24 +0.058 1.68 −0.08 4.15 +0.211
a

Metabolites: (*) represents a material which has not been identified.

b

Variable importance in the projection (VIP≥1) was obtained from OSC-PLS. Oblique line (/) represents no variations of the metabolite between the left group of the subtitle and the right group of the subtitle.

c

Loading: the positive (+) value represents an increase of the metabolite in the right group of the subtitle (e.g.: 20 mg/kg cocaine group of control vs. 20 mg/kg cocaine); while the negative (−) value represents a decrease of the metabolite in the right group of the subtitle; Oblique line (/) represents no variations of the metabolite between the left group of the subtitle and the right group of the subtitle.