Table 2. Temporal changes of H3K4me3 is associated with changes of gene expression in kidney and lung.
| No. of genes | ||||
| Kidney | Lost/decreasedH3K4me3 | H3K4me3unchanged | Acquired/increasedH3K4me3 | Chi-square P-value |
| Whole Genome | 2500 (26.0%) | 4168 (43.4%) | 2929 (30.5%) | |
| Age-downregulated (≥2-fold, FDR<5%) | 381 (50.8%) | 278 (37.1%) | 91 (12.1%) | P<0.001 |
| Age-upregulated (≥2-fold, FDR<5%) | 86 (11.8%) | 216 (29.5%) | 429 (58.7%) | P<0.001 |
| Expression not significantly changed | 2033 (25.0%) | 3674 (45.3%) | 2409 (29.7%) | P = 0.047 |
| No. of genes | ||||
| Lung | Lost/decreased H3K4me3 | H3K4me3 unchanged | Acquired/increased H3K4me3 | Chi-square P-value |
| Whole Genome | 2825 (32.0%) | 3796 (42.9%) | 2220 (25.1%) | |
| Age-downregulated (≥2-fold, FDR<5%) | 314 (57.0%) | 177 (32.1%) | 60 (10.9%) | P<0.001 |
| Age-upregulated (≥2-fold, FDR<5%) | 88 (17.9%) | 164 (33.3%) | 240 (48.8%) | P<0.001 |
| Expression not significantly changed | 2423 (31.1%) | 3455 (44.3%) | 1920 (24.6%) | P = 0.202 |
Genes were categorized by changes in gene expression with age (rows) and changes in histone H3K4me3 with age (columns). In both kidney and lung, age-downregulated genes (≥2-fold, FDR<0.05) were significantly enriched with genes showing loss of or decrease in H3K4me3, Conversely, the set of age-upregulated genes (≥2-fold, FDR<0.05) was significantly enriched with genes showing acquisition of or increase in H3K4me3.