Figure 1. Amount of CFU per gram of bone, quantified in pulverized bone from left tibia postoperation.

The mice were not contaminated with MRSA and received PBS served as controls (group I). The medullary cavities of tibiae in mice were contaminated with MRSA and different doses of anisomycin (15.0 mg/kg, group III and 5.0 mg/kg, group IV) were followed. The animals that received phosphate- buffered saline (PBS) were served as group II. (A) Same treatment conditions for different periods of time; (B) different treatment conditions for the same periods of time. All bones of group I and one of group III were sterile. Values are the mean ± standard deviation (SD). * Statistically significant differences between the 2 groups, p<0.05; # no significant difference, p>0.05.