Figure 4. The in vivo effects of DAC and Ara-C in primary paediatric AML xenografts.

A and B) Cells isolated from BM of three xenografts following 5 or 10 days of treatment were stained for human CD45 and CD33 and for mouse CD45; the proportion of human cells which were CD45⁺CD33⁺ from each treatment group were compared to Ara-C treatment alone in the BM. C) Cells isolated from the spleen which were human CD45⁺CD33⁺ compared to PBS (* P <0.001).