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. 2014 Jan 28;9(1):e87489. doi: 10.1371/journal.pone.0087489

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© 2014 Jujo et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The Western blot analysis revealed that the MMP-14 protein expression in SCLs was higher than that in A549 cells. There was no significant difference in the protein expression of MMP-14 in SCLs incubated in the media with or without growth factors. (B) Batimastat did not suppress the SCLs' expression of the MMP-14 and MMP-2 proteins. (C)(D) The band signal strength of MMP-14 (c) and MMP-2 (d) expressed as a ratio to beta-actin. No significant differences in the signal strength were recognized 24 hours and 48 hours after batimastat exposure between the batimastat and control groups. (“N.S.” showed no significant difference between two groups analyzed by Student's t-test.)