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. 2014 Jan 28;9(1):e87489. doi: 10.1371/journal.pone.0087489

Figure 5. The findings of the three-dimensional culture of SCLs.

Figure 5

Cells were incubated for 12(A and B) or 24 hours (C and D). SCLs proliferated linearly and formed tube-like structures and network-like structures within Matrigel (A), but the A549 (lung adenocarcinoma) cells formed no network structures (B). SCLs incubated with EBM-2 also formed the tube-like structures in the Matrigel (C). Exposure to 10 µM batimastat inhibited the formation of the three-dimensional structures (D). (Scale bars show 300 µm.)