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. 2014 Jan 29;34(5):1942–1948. doi: 10.1523/JNEUROSCI.4461-13.2014

Figure 1.

Figure 1.

NMDA receptor subunit composition changes during early postnatal development. A, Responses to puffed NMDA (left) in a P7 Drd4 ganglion cell at a series of Vholds. The response, averaged within the rectangle, generated a J-shaped I–V plot (middle) that was reduced (right) in the presence of ifenprodil (10 μm). B, Ratio of the current measured at Vhold near +40 mV (INMDA +40 mV) in the presence of ifenprodil relative to the control condition. Numbers of cells for each point are shown in parentheses. Error bars indicate ±SEM. Ratios significantly less than one are indicated (*p < 0.01, **p < 0.001). C1, Ifenprodil reversibly attenuated the NMDA puff response in a P7 Drd4 cell (left; Vhold = +55 mV). C2, Ifenprodil reversibly attenuated INMDA +40 mV in a population of P7 and P14 Drd4 and TRHR cells.