Fig. 4.

Coronal MRI images of the rat brain following status epilepticus demonstrating early edema and later hippocampal injury. First column: Control. Second column: post status epilepticus. (a) and (b): low resolution images acquired at 48 h following administration of saline or pilocarpine respectively. (c) and (d): high resolution images acquired 3 weeks after saline or pilocarpine respectively. (b) Illustrates marked bilateral edema in the hippocampus and unilateral edema in the neocortex. (d) shows significant atrophy of the hippocampus leading to enlargement of the lateral ventricles. Hypointense regions in the CA1,CA3 and dentate gyrus of the hippocampus are evident and hyperintense regions in the right neocortex correspond to the regions of hyperintensity that occurred at 2 days following SE.