Table 2.

Anti-inflammatory effect of the intraperitoneal administration of 5a, b, f, g and of the reference drug (acetylsalicylic–lysine: ASL) in carrageenan-induced rat paw oedema

Sample	Dose (mg/kg)	Oedema (10−2 ml) (mean ± SEM)			Oedema inhibition (%)
		1 h	3 h	5 h	1 h	3 h	5 h
Vehicle (2,5 ml/kg)	–	35.87 ± 4.48	50.66 ± 3.68	56.04 ± 2.91	–	–	–
Acetylsalicylic–lysine (reference drug)	300	13.23 ± 2.69**	26.32 ± 2.44**	29.15 ± 2.87**	63.10	48.03	47.98
5a	50	20.59 ± 2.51*	30.07 ± 3.51*	33.73 ± 4.16*	42.59	40.64	39.8
	100	7.01 ± 3.41**	21.88 ± 1.89**	23.45 ± 2.5**	80.44	56.81	58.15
5b	50	14.62 ± 3.21*	20.78 ± 2*	23.56 ± 2*	59.25	58.98	57.95
	100	2.81 ± 2.06***	14.51 ± 2.98***	20.86 ± 2.21***	92.17	71.36	62.76
5f	50	13.51 ± 3.4**	20.25 ± 2.8**	22.74 ± 3.2**	62.31	60.02	59.42
	100	2.07 ± 2.8***	8.69 ± 2.3***	17.45 ± 2.5***	94.22	82.83	68.85
5g	50	24.37 ± 2.7*	36.09 ± 2.9*	41.95 ± 2.8	32.04	28.75	25.13
	100	12.31 ± 3.2**	28.94 ± 2.4*	33.52 ± 2.3	65.66	42.87	40.18

The values represent the mean difference of volume of paw ± SEM (n = 6)

* p < 0.05, ** p < 0.01, *** p < 0.001 significantly different from control group