Table 3.

Crude and adjusted hazard ratios (HR) of overall survival

	Univariate effect			Multivariate effect
	HR	95 % CI	p	HR	95 % CI	p
Gender
Female	1			1
Male	0.93	[0.52,1.65]	0.793	1.35	[0.64,2.88]	0.431
Age (years)	0.99	[0.96,1.02]	0.54	0.98	[0.95,1.02]	0.363
Karnofsky score
Normal activity (90–100)	1			1
Normal activity with effort (80)	0.78	[0.43,1.43]	0.423	0.77	[0.39,1.51]	0.443
Cares for self, unable to carry on normal activity (60–70)	3.43	[1.47,7.99]	0.004	3.45	[1.32,9.01]	0.011
Type of first surgery
Biopsy/partial	1			1
Subtotal/total	0.99	[0.57,1.74]	0.983	0.95	[0.52,1.74]	0.874
MGMT status
Unmethylated	1			1
Methylated	0.72	[0.37,1.43]	0.35	0.82	[0.38,1.74]	0.602
Not evaluable	0.98	[0.50,1.90]	0.942	0.98	[0.45,2.13]	0.95
Time from original diagnosis
<11 months	1			1
≥11 months	1.66	[0.95,2.90]	0.077	1.52	[0.79,2.91]	0.206
Tumor extension
Unifocal	1
Multifocal	1.14	[0.53,2.45]	0.737
Second surgery
No	1
Yes	0.96	[0.46,1.98]	0.902