Table 3.
Univariate effect | Multivariate effect | |||||
---|---|---|---|---|---|---|
HR | 95 % CI | p | HR | 95 % CI | p | |
Gender | ||||||
Female | 1 | 1 | ||||
Male | 0.93 | [0.52,1.65] | 0.793 | 1.35 | [0.64,2.88] | 0.431 |
Age (years) | 0.99 | [0.96,1.02] | 0.54 | 0.98 | [0.95,1.02] | 0.363 |
Karnofsky score | ||||||
Normal activity (90–100) | 1 | 1 | ||||
Normal activity with effort (80) | 0.78 | [0.43,1.43] | 0.423 | 0.77 | [0.39,1.51] | 0.443 |
Cares for self, unable to carry on normal activity (60–70) | 3.43 | [1.47,7.99] | 0.004 | 3.45 | [1.32,9.01] | 0.011 |
Type of first surgery | ||||||
Biopsy/partial | 1 | 1 | ||||
Subtotal/total | 0.99 | [0.57,1.74] | 0.983 | 0.95 | [0.52,1.74] | 0.874 |
MGMT status | ||||||
Unmethylated | 1 | 1 | ||||
Methylated | 0.72 | [0.37,1.43] | 0.35 | 0.82 | [0.38,1.74] | 0.602 |
Not evaluable | 0.98 | [0.50,1.90] | 0.942 | 0.98 | [0.45,2.13] | 0.95 |
Time from original diagnosis | ||||||
<11 months | 1 | 1 | ||||
≥11 months | 1.66 | [0.95,2.90] | 0.077 | 1.52 | [0.79,2.91] | 0.206 |
Tumor extension | ||||||
Unifocal | 1 | |||||
Multifocal | 1.14 | [0.53,2.45] | 0.737 | |||
Second surgery | ||||||
No | 1 | |||||
Yes | 0.96 | [0.46,1.98] | 0.902 |