Table 4.
Toxicities
| Adverse event | Grade: no. of patients | ||||
|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | |
| Nonhematologic toxicity | |||||
| Hypertension | 2 | 6 | 1 | 1 | – |
| Infection | – | – | – | – | – |
| Wound dehiscence | – | – | 3 | – | – |
| Fatigue | 18 | 5 | 2 | – | – |
| Proteinuria | 7 | 10 | – | – | – |
| Rash | – | – | – | – | – |
| Hyperpigmentation | 2 | – | – | – | – |
| Nausea/vomiting | – | – | – | – | – |
| Hypophonia | 5 | – | – | – | – |
| GI perforation/fistula | – | – | – | – | – |
| Hemorrhage, CNS | 2 | – | – | – | 1 |
| Hemorrhage, GI | – | 1 | 1 | – | – |
| Epistaxis | 2 | – | – | – | – |
| Stroke | – | – | – | 1 | – |
| DVT | – | – | 2 | – | – |
| PE | – | – | – | 2 | – |
| Transaminase elevation | – | – | – | – | – |
| Hematologic toxicity | |||||
| Anemia | 2 | – | – | – | – |
| Neutropenia | 1 | 4 | 7 | 1 | – |
| Thrombocitopenia | 3 | 8 | 5 | 1 | – |