Fig. 4.

F10 treatment results in selective eradication of G48a orthotopic brain tumors in nude mice. H&E staining from brain sections obtained from nude mice bearing G48a xenografts following treatment with vehicle (a, d, g) or F10 at 80 (b, e, h) or 120 mg/kg (c, f, i). F10, or vehicle, was administered i.c. over 7 days using an osmotic pump. Brain tissue from mice treated with vehicle-only revealed extensive infiltration of GBM cells into non-malignant tissue and a significant tumor mass (arrows point to tumor borders). Treatment with F10 at either 80 or 120 mg/kg resulted in extensive necrosis selectively for malignant cells with no apparent damage for non-malignant cells in the contralateral side at the level of the hippocampus. Invasive island of cells were observed in contralateral hippocampus of vehicle-treated animals (arrows in g) (Scale bar 100 μm in c and i, 50 μm in f)