Fig. 5.

F10 treatment results in selective eradication of EphA2-stained G48a cells. EphA2 staining from brain sections obtained from nude mice bearing G48a xenografts following treatment with vehicle only (a, d) or F10 at 80 (b, e) or 120 mg/kg (c, f). Strong EphA2 staining is observed for tumor tissue in vehicle-only treated mice with no EphA2 staining in adjacent non-malignant tissue except in isolated invasive cells (arrows indicate tumor borders and point to invasive cells away from tumor core). EphA2 staining is greatly diminished in region of the residual tumor (indicated by arrows) from mice treated with F10 at 80 mg/kg and is absent in mice treated with F10 at 120 mg/kg (Scale bar 50 μm)