FIGURE 6.

Orientation of the side chain of residues are important for interaction with ions during gating. The positions of cadmium-affected residues are in closed (A) and open (B) states. In the left panels, the teal colored dotted subunit was removed for better visibility of the vestibule interior. Cadmium-affected residues in rP2X4R the homology model in closed and open states are presented in the right panels. Particular cadmium hits are presented as light blue sticks on light blue ribbon segments, and different subunits are presented in orange and dark blue.