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. 2014 Jan 29;5:11. doi: 10.3389/fgene.2014.00011

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Copyright © 2014 Xu, Ciampi and Greenwood.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Sensitivity (tSENS) at different significance thresholds (p-values) and for various analytic strategies. The horizontal axis is −log₁₀ (p), and the vertical axis is the true sensitivity for detecting windows containing at least one associated causal variant, when σ = 0.5. N-All: All tests, standard weighting; N-St2: Stratum 2, standard weighting; P-All: All tests, PolyPhen-2 weights; P-St2: Stratum 2, PolyPhen-2 weights; S-All: All tests; subset of damaging variants; S-St2: Stratum 2, subset of damaging variants.