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. 2014 Jan 21;4(1):e348. doi: 10.1038/tp.2013.121

Figure 2.

Figure 2

Schematization of Lingo-1signaling pathways in the (a) healthy brain, (b) dorsolateral prefrontal cortex (DLPFC) region from schizophrenia sufferers and (c) hippocampus region from schizophrenia sufferers. Akt, protein kinase B (PKB); EGF, epidermal growth factor; EGFR, epidermal growth factor receptor; ERK, extracellular signal-reduced kinase; Lingo-1, leucine-rich repeat and immunoglobulin domain-containing protein; MEK, mitogen-activated protein kinase; NGF, nerve growth factor; NgR, Nogo receptor; P75, P75 neurotrophin receptor; PI3-K, phosphatidylinositide 3-kinase; RhoA, Ras homolog gene family, member A; TrkA, transforming tyrosine kinase protein receptor A; TROY (TNFRSF19), tumor necrosis factor receptor super family, member 19; WNK1, With No Lysine (K).