Figure 4.

Comparison of HFA cases against all parental controls. Genes shaded in dark and light blue are members of or associated with the Ras/Ca²⁺ pathway (Figure 2), respectively (see Figure 1 for legend). PFN2 inhibits the formation of IP₃ and DAG by binding to PIP2, LIMK1 is phosporylated by ROCK1 and PAK1, downstream of RHOA and RAC1, respectively. PTENP1 acts as a decoy for PTEN-targeting miRNAs.⁴⁰ SLC25A21 may be involved in 2-oxodipate acidemia, which is accompanied by mental retardation and learning disabilities.⁴¹ Cytogenic bands: ANO2: 12p13.3, ANO4: 12q23.3.